Larazotide acetate 250 mcg, 60 capsules

INFORMATION:

• The product (substance) is not a food or dietary supplement, not suitable for human consumption.
• Keep out of the reach of children.
• Keep the container tightly closed.
• Store in a dry, cool, shaded place; protect from moisture.
• Store only in the original container.
• Avoid contact during pregnancy and lactation.
• Consult a doctor if you feel unwell or have adverse reactions related to contact with the substance.

Most people have as such an idea of the importance of the microorganisms that inhabit our intestines, or the health of the intestinal barrier, or intestinal mucosa. It determines what is absorbed from our digestive tract and what is eliminated. Along the digestive tract, we have many microvilli, which are finger-like protrusions that increase the area of absorption in our intestines and help absorb all nutrients, but if they become damaged, this can lead to a "leaky" intestinal barrier, or leaky gut syndrome, and thus toxins and heavy metals enter the bloodstream.

Larazotide acetate is a first-in-class regulator of tight junction of the intestinal villi (KJ), being developed as an adjunct to a gluten-free diet. It prevents KJ opening by promoting KJ folding and actin filament regrouping, which prevents gluten from entering the intestinal submucosa and triggering an inflammatory response.

Larazotide is an oral peptide derived from zonula occludens that acts as a tight junction regulator and zonulin antagonist. Tight junctions, also known as tight junctions or zonulae occludentes (singular number, zonula occludens), are multiprotein junctional complexes whose function is to prevent solute and water leakage and seal between epithelial cells. They also play a key role in maintaining the structure and permeability of endothelial cells. Tight junctions can also serve as leaky pathways, creating selective channels for small cations, anions or water. Larazotide binds to intestinal apical cell receptors and antagonizes zonulin, preventing the opening of epithelial tight junctions caused by gluten/gliadin, glyphosate, pro-inflammatory cytokines, bacterial zonulin antigens such as lipopolysaccharide (LPS) and bacterial dysbiosis.