Synephrine 25 mg,60 capsules

Synephrine - natural fat burning support and appetite suppression

Synephrine is a biogenic amine, a substance found in large quantities in the peels of citrus fruits such as bitter orange. Extracts from the fruit or peels of these plants have been used for hundreds of years in traditional Chinese medicine to treat stomach problems and allergies. There is a lot of confusion and controversy around whether Synephrine is safe and what effect it has on the body.

Why it is worth it:

- Increases the breakdown of glucose and glycogen in the liver.
- Increases glucose consumption in muscles by stimulating an enzyme that detects fuel levels in cells and stimulates fat burning.
- Also increases sugar absorption into cells.
- Inhibits α - amylase and α-glucosidase, two enzymes that digest complex starches - this prevents blood sugar spikes after meals.
- Synephrine weakly activates receptors that respond to epinephrine and increase heart rate and blood pressure. Therefore, some researchers have concluded that it is unlikely to cause an increase in blood pressure or heart rate like caffeine.
- Acts as an anti-inflammatory. In cells, Synephrine stops the production of a molecule that signals white blood cells to move toward the inflamed area. It also blocks the activity of an enzyme produced in neutrophils that creates many reactive oxygen species. On the other hand, it reduces the activation of NF-κB. NF-κB plays a role in many inflammatory diseases, such as asthma, inflammatory bowel disease and psoriasis.

There are studies that showed that taking 50 mg of Synephrine helped burn 65 more calories in the first 75 minutes after taking it (source)

The fat-burning process in the body is regulated by chemicals called catecholamines. These molecules bind to receptors on fat cells and trigger the release of stored energy for burning.The problem, however, is that some fat cells are resistant to mobilization. This means they don't respond to catecholamines like other fat cells, which are easier to burn and Synephrine can help mobilize resistant fat cells by blocking the activity of alpha receptors on fat cells.(source)

In other words, Synephrine may prevent alpha receptors in fat cells from inhibiting fat mobilization. Last but not least, anything that has the ability to increase catecholamine activity can also suppress hunger between meals (part of the fight or flight response). Synephrine's appetite-suppressing effects have been demonstrated in animal studies and also have a lot of anecdotal confirmation (many people believe it is an effective appetite suppressant).(source)