LZ1 30 mg

• The product (substance) is not a food or dietary supplement, and is not suitable for human consumption.
• Keep out of the reach of children.
• Keep the container tightly closed.
• Store in a dry, cool, shaded place; protect from moisture.
• Store only in original container.
• Avoid contact during pregnancy and lactation.
• Consult a doctor if you feel unwell or have adverse reactions related to contact with the substance.

Acne is one of the most common epithelial diseases, affecting about 80% of the world's population between the ages of 16 and 35. It is caused by many factors, such as genetic predisposition and hormonal changes, including but not limited to the growth factor IGF-I. Acne associated with IGF-I expression has been implicated in the possible emergence of cancer. The pathology of acne is limited to the hair and sebaceous unit. The evolution of this disease is governed by an increase in sebum production, hyperkeratinization, obstruction of hair follicles and an increase in colonization of Propionibacterium acnes (P. acnes) bacteria present in the skin microbiota. It eventually causes scarring that destroys the self-esteem and quality of life of those who suffer from it.

Acne focuses on chronic inflammation of the pores or hair and sebaceous units consisting of keratinocyte cells, sebaceous glands and hair follicles. There is an increase in the production of dead cells, obstruction of the normal flow of sebum and obstruction by the hair of the mouth of the pore, a plug is formed in which bacteria present in the skin microbiota attack the abscess and cause swelling. For this reason, the most important factors of pathogenesis are - abnormal hyperkeratinization, increased sebum secretion and inflammation of the pores due to the excessive presence of bacterial flora.

LZ-1 is an antimicrobial peptide that was developed to act as an inhibitor of the growth of P. acnes and Staphylococcus epidermis bacteria responsible for acne, it also shows anti-inflammatory activity as it prevents the secretion of cytokines, improving the results achieved by the various peptide molecules contained in LZ1. In studies, it has even shown efficacy against strains of this bacteria that are resistant to Clindamycin. When applied epidermally, it can accelerate the treatment of acne and prevent acne scarring.