MOTS-C 10 mg

INFORMATION:

• The product (substance) is not a food or dietary supplement, not suitable for human consumption.
• Keep out of the reach of children.
• Keep the container tightly closed.
• Store in a dry, cool, shaded place; protect from moisture.
• Store only in the original container.
• Avoid contact during pregnancy and breastfeeding.
• Consult a physician in case of ill health or adverse reactions related to contact.

Healthy aging can be promoted by improving metabolic fitness and physical performance. Mitochondria are major metabolic organelles with a strong impact on aging. In addition to their prominent role in bioenergetics, mitochondria also coordinate broad physiological functions by communicating with other cells through a variety of factors, including peptides encoded in their own independent genome. MOTS-c is a peptide encoded in mitochondria that regulates metabolic homeostasis in response to cellular stress.

MOTS-c is a peptide composed of 16 amino acids, expressed by a mitochondrial gene. Studies provide evidence that mitochondria play a key role in signaling and energy production. MOTS-c regulates metabolic functions throughout the body, including converting glucose into usable energy. Preliminary studies show evidence of improved blood sugar control in people with type 2 diabetes and obesity.

Skeletal muscle is the main target tissue of MOTS-c. Skeletal muscle enhances insulin sensitivity and increases glucose uptake in myocytes (muscle cells) through activation of the AMPK pathway while not increasing insulin levels. One can call MOTS-c an exercise mimetic, meaning that it mimics exercise on the body. Exercise also increases glucose uptake by muscles without insulin stimulation. AMPK (AMP-activated protein kinase) was identified in 1999 as a master metabolic switch and central regulator of glucose and lipid (fat) metabolism. Since then, it has been a target for therapeutic interventions against metabolic conditions such as type 2 diabetes.

Mitochondria are the main cellular sites involved in ATP (energy) production and fatty acid oxidation. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Mitochondria also play a key role in determining metabolic flexibility.